Gene Expression Database (GXD)

Gene Expression Database (GXD) provides comprehensive developmental gene expression data for mice, integrating transcript-level and protein-level expression across multiple mouse strains and mutants to support studies of development and disease models.

Key Features:

• Developmental expression coverage: Curated expression information focused on developmental stages in mice.
• Molecular-level integration: Consolidates expression data at both transcript and protein levels.
• Genetic diversity: Includes expression data from multiple mouse strains and mutants.
• Data curation sources: Incorporates data from scientific literature, individual laboratories, and large-scale data providers.
• Expert annotation: Records are annotated and reviewed by expert curators to ensure accuracy.
• Database integration: Linked and integrated with Mouse Genome Informatics (MGI) and external databases to provide broader biological context.
• Expanded content and querying: Contains an increased volume of expression data and supports a range of simple to complex queries.

Scientific Applications:

• Developmental biology: Mapping spatial and temporal gene expression patterns during mouse development.
• Genetics: Comparing expression across strains and mutants to inform genotype–phenotype relationships.
• Genomics: Enabling genome-scale analyses by integrating transcript and protein expression datasets.
• Disease modeling: Informing interpretation of mouse models of human disease via expression pattern data.

Methodology:

Data are curated from scientific literature, individual laboratories, and large-scale data providers, annotated and reviewed by expert curators, and integrated with Mouse Genome Informatics (MGI) and external databases.