H2V

H2V catalogs human genes and proteins that are differentially expressed in response to SARS-CoV-2, SARS-CoV, and MERS-CoV infections to support analysis of host molecular responses.

Key Features:

• Data Compilation: H2V aggregates curated journal articles and transcriptomic and proteomic datasets that survey SARS-CoV-2, SARS-CoV, and MERS-CoV infections.
• Differential Analysis: The resource employs differential expression analyses to compare gene and protein expression levels between infected and control samples.
• Database Content: H2V contains a compiled list of human genes and proteins that are differentially expressed in response to SARS-CoV-2, SARS-CoV, and MERS-CoV infections.

Scientific Applications:

• Pathogenesis Research: The database supports investigation of host molecular responses and pathways altered during coronavirus infection.
• Drug Target Identification: H2V highlights genes and proteins and their associated pathways that may serve as potential antiviral drug targets.
• Preparedness for Future Emergencies: The compiled differential expression data provide a resource for comparative analyses across coronavirus outbreaks to inform response strategies.

Methodology:

The database was created by reviewing and integrating existing scientific literature and experimental transcriptomic and proteomic data and by applying differential expression analyses to identify genes and proteins altered by SARS-CoV-2, SARS-CoV, and MERS-CoV infection.