HaDeX

HaDeX analyzes hydrogen-deuterium exchange mass spectrometry (HDX-MS) data to quantify and visualize deuterium uptake and support interpretation of protein dynamics and interactions.

Key Features:

• Reproducible Analytical Process: Implements a consistent, reproducible workflow for HDX-MS data analysis.
• Data Exploration and Quality Control: Provides functions for initial data exploration and quality control of HDX-MS experiments.
• Publication-Quality Figures: Generates publication-quality figures for visualizing HDX-MS results.

Scientific Applications:

• Structural Biology: Enables analysis of protein dynamics and interactions at the molecular level using HDX-MS data.
• Mechanism Elucidation: Supports mapping of conformational changes and interaction sites to elucidate mechanisms of action.
• Drug Target Characterization: Aids identification and characterization of potential drug targets and biomolecular complexes.

Methodology:

Aligns with emerging standards in HDX-MS data analysis and applies a comprehensive approach to data handling, from initial processing to advanced visualization.