HAMdb

HAMdb catalogs human autophagy modulators and their annotations to support research on autophagy mechanisms, pathways, and disease associations.

Key Features:

• Content scope: Curated information on autophagy modulators including proteins, chemicals, and microRNAs and their associated pathways and disease contexts.
• Entry counts: Contains detailed entries for 796 proteins, 841 chemicals, and 132 microRNAs.
• Annotations: Entries are annotated with specific effects on autophagy, physicochemical properties, biological functions, and related disease information.
• Curation: Data were compiled through manual curation to ensure accuracy and relevance.
• Pathway and disease linkage: Consolidates pathway and disease information related to autophagy modulators.
• Cross-references: Provides external links to additional biomedical resources and references.

Scientific Applications:

• Drug discovery: Facilitates identification of candidate autophagy modulators for therapeutic development.
• Target identification: Supports discovery of diagnostic markers and therapeutic targets related to autophagy.
• Mechanistic studies: Enables investigation of modulators' effects on autophagy pathways and biological functions.
• Disease research: Supports research into autophagy involvement in metabolic conditions, neurodegenerative diseases, cancers, and infectious diseases.

Methodology:

Data were compiled through manual curation and annotated with effects on autophagy, physicochemical properties, biological functions, and pathway and disease associations.