hCoronavirusesDB

hCoronavirusesDB provides a curated repository of nucleotide and protein sequences and experimentally validated B cell and T cell epitope data for SARS-CoV, SARS-CoV-2, and MERS-CoV to support molecular surveillance and genetic and immunogenic analyses.

Key Features:

• Extensive Sequence Data: Comprehensive repository of nucleotide and protein sequences for SARS-CoV, SARS-CoV-2, and MERS-CoV enabling comparative genetic analyses.
• Bioinformatics Analytics and Visualization Tools: Integrated bioinformatics analytics and visualization tools for sequence analysis and evolutionary tracking.
• Curated Epitope Data: Contains curated, experimentally validated B cell and T cell epitope data for immunological and vaccine-related analyses.

Scientific Applications:

• Molecular Surveillance and Monitoring: Tracing viral circulation and microevolutionary changes through sequence comparison and variant tracking.
• Vaccine and Therapeutic Development: Identifying immunogenic targets and supporting rational vaccine and therapeutic design using sequence and epitope data.
• Diagnostic Tool Development: Supporting development of pan-coronavirus diagnostic assays through comparative sequence and epitope information.

Methodology:

Maintains a repository of nucleotide and protein sequences, integrates bioinformatics analytics and visualization tools for sequence and evolutionary analyses, and curates experimentally validated B cell and T cell epitope data.