HDVdb

HDVdb provides a centralized repository of Hepatitis D virus (HDV) partial and complete genomic sequences and analysis tools to support studies of HDV genetic variability, genotyping, and epidemiology.

Key Features:

• Comprehensive Sequence Collection: Contains partial and complete HDV genomic sequences sourced from GenBank and an internal patient cohort.
• Genotype and Subtype Classification: Supports provisional classification into eight major genotypes and various subtypes of HDV.
• Sequence Annotation: Offers sequence annotation capabilities for HDV genomic data.
• Genotyping: Provides computational genotyping of HDV sequences.
• Primer Prediction: Includes primer prediction functionality for assay and experimental design.
• Phylogenetic Analyses: Enables phylogenetic analyses of HDV sequences to assess evolutionary relationships.
• Hypervariable Region Analysis: Facilitates analysis of the HDV hypervariable region to evaluate sequence variability.
• Drug-resistance Mutation Analysis: Supports identification and investigation of drug-resistant mutations in HDV sequences.

Scientific Applications:

• Genetic variability studies: Enables characterization of sequence diversity across HDV genomes and the hypervariable region.
• Genotype–epidemiology correlations: Supports analyses linking HDV genotypes and subtypes to epidemiological patterns.
• Pathogenesis research: Facilitates investigation of genotype-associated differences in HDV pathogenesis.
• Drug-resistance monitoring: Aids identification and study of mutations associated with antiviral resistance.
• Assay and primer design: Provides primer prediction to support development of molecular diagnostics and experimental assays.
• Vaccine and therapeutic development support: Supplies sequence and genotype data relevant to design and evaluation of HDV therapeutics and vaccines.

Methodology:

Sequences are integrated from GenBank and an internal patient cohort; provided computational functions include sequence annotation, genotyping, primer prediction, and phylogenetic analyses.