HDX WorkBench

HDX WorkBench analyzes hydrogen/deuterium exchange mass spectrometry (HDX-MS) data to quantify protein conformational dynamics and map structural changes.

Key Features:

• Automation: Automates data handling and processing steps for HDX-MS experiments.
• Data Management: Organizes and stores large HDX-MS datasets for systematic access and workflow integration.
• Visualization: Generates graphical representations of HDX-MS data to aid interpretation of protein dynamics and conformational changes.
• Statistical Cross-Comparison: Performs statistical comparisons across datasets to validate experimental differences across conditions or time points.
• Real-Time Analysis: Supports validated data analysis at the rate of generation to provide timely results during experiments.

Scientific Applications:

• Structural Biology: Enables analysis of protein conformation and dynamics from HDX-MS experiments.
• Drug Discovery: Supports investigation of conformational changes and interaction networks relevant to target characterization.
• Biophysics: Assists quantitative characterization of protein structural dynamics and interaction networks under different physiological conditions.

Methodology:

Automated data handling combined with visualization and statistical cross-comparison methods for validated, real-time analysis of high-throughput HDX-MS datasets.