HemaExplorer

HemaExplorer provides access to a curated collection of processed mRNA gene expression profiles from mouse and human hematopoietic stem, progenitor, and differentiated cells, including human acute myeloid leukemia subtypes, to enable comparative analysis between leukemic and normal counterparts.

Key Features:

• Curated Database: Contains processed mRNA gene expression profiles from mouse and human hematopoietic stem and progenitor cells as well as differentiated cell types, including distinct human acute myeloid leukemia subtypes.
• Data Integrity: Maintains profile quality through rigorous normalization and batch correction procedures.

Scientific Applications:

• Leukemia Research: Enables comparison of gene expression profiles across human acute myeloid leukemia subtypes and normal hematopoietic cells to investigate leukemic transformations and potential therapeutic targets.
• Immunology and Cell Differentiation Studies: Supports analysis of gene expression changes underlying immune cell differentiation and function.
• Hematopoietic Biology: Facilitates exploration of gene expression dynamics across different maturation stages of the hematopoietic system.

Methodology:

Processed mRNA gene expression profiles with normalization and batch correction.