HemAtlas

HemAtlas maps hematopoiesis across species and developmental stages through systematic integration of multi-omics datasets.

Key Features:

• Multi-species Integration: HemAtlas integrates multi-omics datasets from humans, mice, zebrafish, and HSPC in vitro culture systems.
• Literature Curation and Data Normalization: HemAtlas utilizes literature curation and data normalization to integrate various functional modules for omics data exploration.
• Organ-wide Hematopoietic References: HemAtlas constructs organ-wide hematopoietic references for each species with manually curated cell annotations through systematic and uniform integration methods.
• Single-cell Cross-stage Analysis: HemAtlas performs single-cell cross-stage analysis to elucidate hematopoietic development.
• Cross-species Analysis: HemAtlas performs cross-species analysis to compare hematopoiesis across zebrafish, mice, and humans.
• Cross-model Analysis: HemAtlas performs cross-model analysis to offer guidance on the generation of HSPCs in vitro.
• HSPC Cross-stage Development Map: HemAtlas incorporates a comprehensive map of HSPC cross-stage development to reveal HSPC stage-specific properties.

Scientific Applications:

• Hematopoietic Developmental Landscape Construction: HemAtlas enables comprehensive decoding of cross-stage developmental hematopoiesis at the organ level across species.
• In Vitro HSPC Generation Guidance: HemAtlas offers guidance on the generation of functional hematopoietic stem and progenitor cells in vitro through cross-model analyses.
• HSPC Stage-specific Property Investigation: HemAtlas reveals HSPC stage-specific properties through its comprehensive cross-stage development map.

Methodology:

HemAtlas employs literature curation and data normalization for data integration, and applies a systematic and uniform integration method to construct organ-wide hematopoietic references with manually curated cell annotations.