HERVd

HERVd catalogs and classifies human endogenous retroviruses (HERVs), integrating refined classification of divergent HERV families with human genome annotations to support research on HERV diversity, distribution, and potential roles in gene regulation and disease.

Key Features:

• Enhanced classification of divergent HERV families: Refines categorization of HERV families that exhibit significant divergence from canonical retroviral genomes to improve family-level assignment.
• Precise member identification: Supports more accurate identification of individual HERV loci within each family, aiding discrimination of closely related elements.
• Integration with human genome annotation: Links HERV entries to human genome annotations to contextualize HERV loci with nearby genes and genomic features.

Scientific Applications:

• Evolutionary analysis: Enables studies of HERV family evolution and divergence across the human genome.
• Functional genomics: Facilitates investigation of potential HERV influences on gene regulation by providing genomic context.
• Disease association studies: Supports research into associations between HERV loci and diseases, including cancer and neurological disorders.
• Population genomics: Aids analysis of HERV diversity and distribution across human populations.

Methodology:

Refinement of HERV family classification for divergent retroviral sequences and integration/mapping of HERV loci to human genome annotations.