HExpoChem

HExpoChem integrates curated chemical exposure and chemical-protein interaction data with protein and chemical interaction networks to enable exploration of molecular mechanisms and assessment of potential human health risks from environmental chemicals.

Key Features:

• Integration of Chemical-Protein Interactions: Focuses on interactions between environmental chemicals and human proteins to link chemicals to molecular targets.
• Enriched Interaction Networks: Enhances chemical-protein interaction data with a quality-scored human protein-protein interaction network, a protein-protein association network, and a chemical-chemical interaction network.
• Analysis of Protein Complexes and Phenotypic Outcome Enrichment: Leverages enriched networks to study protein complex formation and the enrichment of phenotypic outcomes to support prediction of potential adverse health effects.

Scientific Applications:

• Pathway disruption analysis: Investigates how specific chemicals may disrupt biological pathways.
• Biomarker identification: Identifies potential biomarkers of chemical exposure through protein interaction networks.
• Phenotypic outcome assessment: Explores broader implications of chemical interactions on human health by examining phenotypic outcomes and predicting adverse effects.

Methodology:

Curating and integrating diverse datasets related to environmental chemicals, their bioactivities, and various interaction networks.