HFBD

HFBD curates a manually collected and annotated database of heart failure (HF) biomarkers to support analysis of HF heterogeneity and precision-medicine applications.

Key Features:

• Coverage: 2,618 records describing 868 distinct biomarkers compiled from 1,237 PubMed articles.
• Biomarker grouping: Includes 731 single biomarkers and 137 combined biomarkers.
• Biological levels: Classifies biomarkers across molecular (proteins, RNAs, DNAs), image, cellular, and physiological levels.
• Annotations: Each entry contains biological relevance, clinical implications, and the specific experimental methodologies reported for discovery.
• Disease focus: Concentrates on biomarkers associated with heart failure (HF) and its heterogeneity.

Scientific Applications:

• Precision medicine: Enables analysis of HF heterogeneity to inform personalized diagnosis and treatment strategies.
• Biomarker research: Serves as a reference for discovery, comparison, and selection of HF biomarkers across molecular, cellular, image, and physiological domains.
• Clinical translation: Supports development of diagnostic tools and therapeutic interventions tailored to individual HF patient profiles.

Methodology:

Manual curation from PubMed literature yielding 2,618 records from 1,237 original articles with extraction and annotation of biomarker identity, grouping, biological level, and reported experimental methodologies.