HGPD

The Human Gene and Protein Database (HGPD) provides a curated repository of human Gateway entry clones, linked protein expression and synthesis data, and in vivo cellular localization information to support proteomic and genetic analysis.

Key Features:

• Extensive Collection: Contains 43,249 human Gateway entry clones constructed from open reading frames (ORFs) of full-length cDNA.
• HuPEX Resource: The clone set is designated as the Human Proteome Expression Resource (HuPEX).
• Functional Classification: Clones are organized into 10 functional groups based on protein function.
• In Vivo Localization Data: Includes cellular localization data for 32,651 human Gateway entry clones.
• Protein Expression and Synthesis Data: Provides comprehensive data on protein expression and synthesis linked to the clones.
• ORF Region Provided: The ORF region of each cDNA is provided to enable precise retrieval of clone-associated data.

Scientific Applications:

• Therapeutic Development: Supports development of new medicines and medical treatments by supplying Gateway entry clones and expression data for functional studies.
• Diagnostic Method Development: Supports development and improvement of diagnostic methods by linking ORFs, expression profiles, and localization data.
• Gene and Protein Function Studies: Enables investigation of gene function, protein expression, and intracellular localization in proteomic analyses.
• Resource for Proteomics: Serves as a repository for experimental expression and localization studies using full-length cDNA-derived clones.

Methodology:

Curation and construction of human Gateway entry clones from ORFs of full-length cDNA, classification of clones into 10 functional groups, and integration of protein expression/synthesis and in vivo cellular localization data.