HGTphyloDetect

HGTphyloDetect performs identification and phylogenetic analysis of horizontal gene transfer (HGT) events to reveal donor lineages and evolutionary dynamics driving genome evolution and metabolic adaptation.

Key Features:

• High-Throughput Analysis: Handles large-scale genomic datasets for genome-wide identification of putative HGT events.
• Phylogenetic Inference: Implements phylogenetic reconstruction to infer potential gene donors and trace transmission paths among evolutionarily distant and closely related species.
• Accuracy and Low False Discovery Rate: Identifies HGT events with high precision and a low false discovery rate.

Scientific Applications:

• Evolutionary Biology: Dissects how HGT contributes to genome evolution and the acquisition of novel functions.
• Comparative Genomics: Enables genome-wide surveys of HGT to contextualize gene distribution across species and infer evolutionary relationships.
• Microbial Ecology: Assists in analyzing how HGT mediates metabolic adaptation and ecological interactions in microbial communities.

Methodology:

Combines high-throughput genomic data processing with phylogenetic reconstruction methods to identify candidate HGT loci and reconstruct their evolutionary histories and transmission paths.