HHMD

HHMD integrates human histone modification datasets to support analyses of chromatin remodeling, transcriptional regulation, stem cell maintenance, differentiation, and cancer-associated epigenetic dysregulation.

Key Features:

• Coverage: Contains data for 43 location-specific histone modifications.
• Modification types: Includes methylation, acetylation, and ubiquitylation annotations.
• Experimental sources: Integrates datasets derived from ChIP-seq, ChIP-chip, and qChIP experiments.
• Searchable fields: Provides queryable indexes by histone modification type, gene ID, functional category, chromosome location, and cancer name.
• Visualization: Supports genome-wide visualization of histone modification maps via HisModView.
• Manual curation: Contains curated information on histone modification dysregulation across nine human cancers.

Scientific Applications:

• Chromatin remodeling studies: Enables mapping of modification patterns relevant to chromatin structure and remodeling.
• Transcriptional regulation analyses: Facilitates correlation of histone modifications with gene expression and regulatory states.
• Stem cell and differentiation research: Supports investigation of histone modification roles in stem cell maintenance and lineage differentiation.
• Cancer epigenetics: Provides curated dysregulation data to study oncogenic histone modification alterations across nine cancers.
• Genome-wide comparative analyses: Allows comparative mapping of histone modification profiles across loci, genes, chromosomes, and cancer types.

Methodology:

Integrates and indexes data derived from ChIP-seq, ChIP-chip, and qChIP experiments, provides genome-wide visualization via HisModView, and includes manual curation of dysregulated histone modifications in nine human cancers.