HiCMC

HiCMC compresses Hi-C contact matrices by modeling underlying structural properties such as compartments and domains to achieve efficient data reduction and accelerate downstream analyses.

Key Features:

• Structural modeling: HiCMC models compartments and domains found in Hi-C contact matrices to achieve compression.
• Domain-specific information integration: HiCMC embeds domain-specific information into compressed bitstreams for downstream analysis acceleration.
• Cross-resolution performance: HiCMC operates across multiple cell lines and contact matrix resolutions.

Scientific Applications:

• Hi-C data storage: HiCMC reduces storage requirements for genome-wide chromosome conformation capture data.
• Dynamic chromosome organization studies: HiCMC enables efficient storage of time-series Hi-C snapshots for analyzing dynamic chromosome organization.
• Downstream analysis acceleration: HiCMC leverages integrated domain information in compressed bitstreams to speed up subsequent computational analyses.

Methodology:

HiCMC models underlying structures found in the contact matrix, specifically compartments and domains, to compress Hi-C data.