HiCube

HiCube visualizes Hi-C contact maps alongside 3D genome structures to enable integrated, multiscale exploration of genomic architecture and spatial chromosomal interactions.

Key Features:

• Multiscale Visualization: Enables visualization of genomic data across multiple resolutions for examination at different levels of granularity.
• Synchronized Hi-C and 3D Integration: Provides synchronized display of Hi-C contact maps together with 3D genome structures to link contact frequency patterns with spatial configurations.

Scientific Applications:

• 3D Genome Organization: Facilitates analysis of three-dimensional genome folding and structural domains from Hi-C and 3D coordinate data.
• Chromosomal Interactions and Gene Regulation: Supports investigation of spatial proximity and contacts relevant to regulatory interactions and gene expression control.
• Chromosome Architecture and Cellular Processes: Assists study of chromosome architecture relationships to cellular processes by correlating contact maps with spatial models.

Methodology:

Implemented in JavaScript and performs synchronized visualization of Hi-C contact maps and 3D genome structures.