HIGDB

HIGDB provides centralized access to bacteriological, clinical, genomic, proteomic, and structural data for Haemophilus influenzae to support comparative genomics, molecular research, and clinical investigations.

Key Features:

• Bacteriological and clinical data: Consolidated bacteriological and clinical datasets related to Haemophilus influenzae.
• Proteomic data: Detailed information on 42,741 proteins associated with H. influenzae.
• Genomic information: Records for 18,077 genes including sequences from 10 whole genomes.
• Structural biology: Access to 284 three-dimensional protein structures of H. influenzae.
• Motif search capability: Tools for identifying DNA motifs within H. influenzae genomes to support comparative analyses.
• GBrowse integration: Genome browser integration for visualization and comparison of gene and protein sequences across strains.

Scientific Applications:

• Comparative genomics: Comparative analysis of genomic sequences across multiple H. influenzae strains.
• Molecular biology research: Investigation of gene and protein function using integrated genomic, proteomic, and structural data.
• Clinical investigations: Studies of pathogenic mechanisms and development of targeted treatment strategies.
• Evolution and resistance studies: Analysis of bacterial evolution, virulence factors, and antibiotic resistance patterns.

Methodology:

Deployed on a Solaris server with data stored and managed in MySQL; implemented using PERL modules, Ajax, and JavaScript; integrates GBrowse for genome visualization.