HIHISIV

HIHISIV integrates gene expression data associated with HIV and SIV infection in both hosts and pathogens to facilitate research on lentiviral pathogenesis and host immune response.

Key Features:

• Data Integration: The database combines microarray and RNA-Seq gene expression data selected, curated, analyzed, enriched, and stored in a relational database.
• Query Templates: Six query templates comprise the main data analysis functions.
• Data Download: Resulting information from queries can be downloaded.
• Browsing and Visualization: The database provides resources for browsing and visualizing results.

Scientific Applications:

• Lentiviral Pathogenesis Research: Supports investigation of host-pathogen interactions and disease progression in HIV and SIV infections.
• Comparative Transcriptomics: Enables integration and evaluation of transcriptional data across human and nonhuman primate hosts in the presence or absence of HIV or SIV.
• Immune Response Analysis: Facilitates study of host immune responses to lentiviral infection using pre-existing transcriptome data.

Methodology:

Gene expression datasets were selected, curated, analyzed, enriched, and stored in a relational database.