HIResist

HIResist catalogs HIV-1 envelope glycoprotein (Env) sequence data and computationally identifies sequence patterns associated with resistance to broadly neutralizing antibodies (bnAbs) to support analysis of bnAb escape mechanisms.

Key Features:

• Data Repository: Compiles HIV-1 envelope (Env) sequence datasets annotated for resistance or sensitivity to specific broadly neutralizing antibodies (bnAbs).
• Computational Tools: Performs bioinformatic analyses to identify sequence patterns and signatures associated with resistant strains and to compare resistant versus sensitive HIV-1 strains.
• Mechanism Elucidation: Links sequence signatures to phenotypic resistance to support analysis of mechanisms by which HIV-1 escapes bnAb-mediated neutralization.
• Research Applications: Supports discovery of resistant features in HIV-1 strains and informs studies aimed at overcoming bnAb resistance.

Scientific Applications:

• Resistance determinant discovery: Identify sequence determinants of resistance and sensitivity to bnAbs across HIV-1 Envs.
• Comparative strain analysis: Compare resistant and sensitive HIV-1 strains to reveal resistance and sensitivity signatures linked to particular bnAbs or bnAb groups.
• Mechanistic investigation: Investigate mechanisms of bnAb escape mediated by Env sequence variation.

Methodology:

Compiles annotated HIV-1 Env sequence datasets and applies computational analyses to identify sequence patterns and perform comparative analyses between resistant and sensitive strains to pinpoint resistance and sensitivity signatures linked to bnAbs.