HISSTA

HISSTA archives and analyzes human in situ single-cell transcriptome data from MERFISH, CosMx SMI, and Xenium techniques across 112 samples and 28 million cells encompassing 16 tissue types from 63 studies.

Key Features:

• Cell Type Annotation: HISSTA implements tools for annotating cell types in spatial transcriptome data.
• Spatial Colocalization Analysis: HISSTA provides methods to analyze spatial colocalization patterns between cell types.
• Spatial Cellular Communication: HISSTA includes tools for inferring cellular communication based on spatial proximity.
• Niche Analysis: HISSTA enables analysis of cellular niches within tissue microenvironments.
• Interactive Visualization: HISSTA provides interactive data access through Vitessce for examining gene expression and focusing on regions of interest.

Scientific Applications:

• Cancer Diagnosis: HISSTA supports cancer diagnosis through comprehensive spatial transcriptome analysis.
• Precision Medicine: HISSTA enables precision medicine approaches by providing detailed single-cell spatial transcriptome data.
• Digital Pathology: HISSTA facilitates digital pathology through spatially resolved transcriptomic profiling of human tissues.

Methodology:

HISSTA collects and annotates spatial transcriptome data generated by MERFISH, CosMx SMI, and Xenium techniques, with interactive accessibility through Vitessce.