HIstome

HIstome catalogs a manually curated relational database of 55 human histone proteins, 106 post-translational modification (PTM) sites, and 152 histone-modifying enzymes to support analysis of histone variants, PTMs, and enzyme-mediated chromatin regulation.

Key Features:

• Histone Proteins: Contains detailed entries for 55 human histone proteins, including histone variants.
• Post-Translational Modifications (PTMs): Catalogs 106 distinct PTM sites associated with those histones.
• Histone-Modifying Enzymes: Includes data on 152 enzymes responsible for addition and removal of histone modifications, categorized by catalytic function.
• Categorizations: Organizes entries into five types of histones, eight types of PTMs, and fourteen categories of modifying enzymes.
• Relational Database Structure: Implements a relational schema linking histone proteins, PTM sites, and modifying enzymes to enable cross-referenced queries.

Scientific Applications:

• Epigenetics research: Supports analysis of histone variants and PTM patterns underlying chromatin structure and gene regulation.
• Pharmacology and target discovery: Facilitates identification and annotation of histone-modifying enzymes relevant to drug development.
• Clinical and translational studies: Enables investigation of histone modification patterns and enzyme dysregulation in pathological conditions.
• Gene regulation studies: Aids exploration of how specific PTMs and modifying enzymes contribute to transcriptional control.

Methodology:

Manually curated from up-to-date scientific literature and implemented as a relational database linking histone proteins, PTM sites, and modifying enzymes.