HiView

HiView integrates Hi-C chromatin interaction data with GWAS variants to link non-coding genetic variants to candidate target genes and regulatory elements.

Key Features:

• Integration of Hi-C data: Combines Hi-C chromatin conformation capture data with GWAS variant loci to reveal spatial genome organization relevant to variant interpretation.
• Visualization of chromatin interactions: Displays statistical evidence for chromatin interactions within genomic regions surrounding specific GWAS variants to support hypotheses about regulatory links.
• Linking distal regulatory elements to target genes: Provides an interactome view that associates distal regulatory elements with potential target genes to guide post-GWAS functional follow-up.

Scientific Applications:

• Functional annotation of non-coding GWAS variants: Facilitates assignment of regulatory function to variants located in non-protein-coding regions by identifying interacting regulatory elements and genes.
• Prioritization of candidate target genes: Helps prioritize genes for experimental validation by linking GWAS loci to physically interacting promoters or gene bodies.
• Investigation of chromatin architecture in disease: Enables study of how three-dimensional genome organization contributes to complex traits and disease-associated genetic variation.

Methodology:

Integrates Hi-C chromatin conformation capture measurements with regulatory-element annotations from ENCODE and Roadmap Epigenomics and generates statistical evidence and a catalog of potential gene–regulatory element interactions linking GWAS variants to candidate targets.