hla-net

hla-net analyzes HLA-DPB1 allele distributions from genetic data in UNIFORMAT v3 to support population genetics and immunogenetics studies.

Key Features:

• Target locus: Focuses analysis specifically on HLA-DPB1 alleles.
• Data handling: Processes plain text files in UNIFORMAT v3 format for input genotype data.
• Population genetics analysis: Performs allele frequency and population genetics analyses using GENE[RATE].
• Empirical application: Applied to datasets derived from next-generation sequencing (NGS) HLA typing in reported studies.

Scientific Applications:

• Transplant immunology: Supports analysis of HLA allele distributions relevant to donor–recipient matching.
• Disease association studies: Enables investigation of HLA-DPB1 allele frequencies in relation to disease susceptibility.
• Evolutionary biology: Provides allele frequency data for studies of human population history and dynamics.

Methodology:

Processing of plain text UNIFORMAT v3 files, HLA typing by next-generation sequencing (NGS) in the referenced study, and population genetics analyses conducted with GENE[RATE] on a cohort of 100 unrelated Russian blood donors from the Chelyabinsk region (ages 18–55).