HMDD

HMDD catalogs experimentally supported human microRNA–disease associations to enable analysis of miRNA roles in human disease and aid biomarker and therapeutic target discovery.

Key Features:

• Content scope: HMDD v4.0 curates 53,530 experimentally supported human microRNA–disease association entries (PMID: 37650649), representing a 1.5-fold expansion over HMDD v3.0.
• Exosomal miRNAs: Includes entries for exosomal miRNAs implicated in human diseases.
• Virus-encoded miRNAs: Contains virus-encoded miRNAs involved in human diseases.
• miRNA–circRNA interactions: Documents miRNA–circRNA interaction entries linked to disease contexts.
• Sex-biased miRNAs: Curates sex-biased miRNAs associated with various human diseases.
• Literature curation: Aggregates experimentally supported associations extracted from scientific literature.
• Disease similarity analysis: Employs disease similarity analysis to reveal associations among diseases and miRNA sets.

Scientific Applications:

• Biomarker and therapeutic target discovery: Facilitates identification of candidate miRNA biomarkers and therapeutic targets for human diseases.
• miRNA functional analysis: Supports investigation of molecular functions of miRNAs across biological processes and disease states.
• Sex-difference studies: Enables analysis of sex-biased miRNAs to study sex-specific disease mechanisms.
• Extracellular and viral miRNA research: Supports studies of exosomal and virus-encoded miRNAs in disease etiology.
• Non-coding RNA interaction studies: Enables exploration of miRNA–circRNA interactions in disease contexts.
• Disease network analysis: Supports use of disease similarity analysis to uncover relationships between disorders via shared miRNA associations.

Methodology:

HMDD v4.0 compiles experimentally supported associations by manual literature curation and applies disease similarity analysis as reported (PMID: 37650649).