HORDB

HORDB provides a curated database of 6,024 peptide-hormone-related entries (5,729 distinct peptide hormones, 40 peptide drugs, 255 marketed pharmaceutical preparations) with sequences, activity parameters, structural details, physical properties, and literature references to support research in endocrinology, pharmacology, and peptide therapeutics.

Key Features:

• Database content: 6,024 entries comprising 5,729 distinct peptide hormones, 40 peptide drugs, and 255 marketed pharmaceutical preparations.
• Entry annotations: Each entry contains general information, peptide sequence, activity profile, structural details, physical properties, and literature references.
• Activity parameters: Detailed activity data include IC50, EC50, ED50, target specificity, and blood–brain barrier crossing information.
• Sequence analysis tools: Inclusion of sequence analysis tools for investigation of peptide sequences.
• Structural and physical data: Structural details and physical property annotations are provided for represented peptides.
• Curated references: Literature references are linked to support the provenance of annotations.

Scientific Applications:

• Endocrinology research: Comparative and functional analysis of peptide hormones across organisms and physiological processes.
• Pharmacology and drug discovery: Evaluation of peptide drugs and marketed preparations for therapeutic development and target specificity studies.
• Peptide design and discovery: Use of sequence and activity data to guide design of novel peptide hormones and therapeutic candidates.
• Blood–brain barrier studies: Analysis of peptide properties related to blood–brain barrier permeability and CNS targeting.

Methodology:

Manual curation of peptide hormone entries from literature and incorporation of sequence data, activity parameters, structural annotations, physical properties, and sequence analysis tools.