HPREP

HPREP catalogs amino acid repeats across the human proteome and links repeat instances to functional annotations and disease-associated variation.

Key Features:

• Comprehensive Repeat Identification: Identifies amino acid repeats, including tandem and domain repeats, in UniProtKB/Swiss-Prot human protein sequences using T-REKS and XSTREAM with Perl-based processing.
• Functional Annotation: Annotates proteins with functional information that relates specific repeat types to protein activity and biological processes.
• Mutational Analysis: Contains mutational data for repeat regions to assess the impacts of variations on protein function and stability.
• Disease Correlation: Links repeats and their variations to disease information to support analysis of repeat expansions and other pathological consequences.

Scientific Applications:

• Protein structural analysis: Investigate how amino acid repeats contribute to protein structure and stability.
• Functional characterization: Study the effects of repeats on protein activity and cellular processes.
• Disease association studies: Explore genetic bases of disorders linked to repeat expansions or mutations.
• Comparative proteomics: Compare repeat composition across protein families to identify conserved or divergent repeat patterns.

Methodology:

Perl-based processing of UniProtKB/Swiss-Prot human protein sequences with repeat detection performed by T-REKS (novel repeat detection) and XSTREAM (domain repeat analysis), with results integrated via HTML.