hPSCreg
hPSCreg provides a centralized, searchable registry of human embryonic and induced pluripotent stem cell lines (hESC and hiPSC) to document standardized biological and legal metadata, ethical provenance, and clinical study registration for use in regenerative medicine, disease modeling, and drug development.
Key Features:
- Centralized Data Repository: Stores standardized biological and legal metadata for registered hESC and hiPSC lines in a searchable database.
- Standardized Nomenclature: Automatically generates a unique standardized name for each registered cell line to ensure unambiguous identification.
- Ethical and Biological Verification: Verifies ethical and biological conformity of registered lines against community standards, including documentation of cell sourcing, privacy protection measures, and compliance with ethical guidelines.
- Clinical Studies Registry: Maintains a registry of clinical studies involving hPSCs to provide an overview of trials and study registrations.
- Quality Assurance and Certification: Certifies the quality and ethical provenance of hPSC lines to support comparability of quality standards across research and clinical use.
Scientific Applications:
- Regenerative Medicine: Provides provenance and quality metadata to support development and evaluation of hPSC-based cell therapies.
- Disease Modeling and Drug Screening: Enables selection of well-characterized hPSC lines for disease modeling and compound testing.
- Clinical Research and Regulation: Supports registration, tracking, and regulatory review of clinical studies by documenting provenance, ethics, and quality information.
- Reproducibility and Data Integration: Promotes reproducibility and data aggregation across studies through standardized nomenclature and metadata.
Methodology:
Automatic generation of unique standardized cell line names and centralized storage of standardized biological and legal metadata for registered hESC and hiPSC lines.
Topics
Details
- Maturity:
- Mature
- Tool Type:
- web application
- Added:
- 10/29/2021
- Last Updated:
- 11/24/2024
Operations
Publications
Seltmann S, Lekschas F, Müller R, Stachelscheid H, Bittner M, Zhang W, Kidane L, Seriola A, Veiga A, Stacey G, Kurtz A. hPSCreg—the human pluripotent stem cell registry. Nucleic Acids Research. 2015;44(D1):D757-D763. doi:10.1093/nar/gkv963. PMID:26400179. PMCID:PMC4702942.
Kurtz A, Seltmann S, Bairoch A, Bittner M, Bruce K, Capes-Davis A, Clarke L, Crook JM, Daheron L, Dewender J, Faulconbridge A, Fujibuchi W, Gutteridge A, Hei DJ, Kim Y, Kim J, Kokocinski AK, Lekschas F, Lomax GP, Loring JF, Ludwig T, Mah N, Matsui T, Müller R, Parkinson H, Sheldon M, Smith K, Stachelscheid H, Stacey G, Streeter I, Veiga A, Xu R. A Standard Nomenclature for Referencing and Authentication of Pluripotent Stem Cells. Stem Cell Reports. 2018;10(1):1-6. doi:10.1016/j.stemcr.2017.12.002. PMID:29320760. PMCID:PMC5768986.
Mah N, Seltmann S, Aran B, Steeg R, Dewender J, Bultjer N, Veiga A, Stacey GN, Kurtz A. Access to stem cell data and registration of pluripotent cell lines: The Human Pluripotent Stem Cell Registry (hPSCreg). Stem Cell Research. 2020;47:101887. doi:10.1016/j.scr.2020.101887. PMID:32707486.
Kobold S, Guhr A, Mah N, Bultjer N, Seltmann S, Seiler Wulczyn AE, Stacey G, Jie H, Liu W, Löser P, Kurtz A. A Manually Curated Database on Clinical Studies Involving Cell Products Derived from Human Pluripotent Stem Cells. Stem Cell Reports. 2020;15(2):546-555. doi:10.1016/j.stemcr.2020.06.014. PMID:32679065. PMCID:PMC7419703.