HPVsim

HPVsim creates flexible agent-based models of human papillomavirus transmission and cervical disease progression parameterized with country-specific vital dynamics, structured sexual networks, and co-transmitting HPV genotypes.

Key Features:

• Agent-based modeling: Simulates HPV transmission and cervical disease through individual-based simulation with structured sexual networks and multiple co-transmitting HPV genotypes.
• Multiscale modeling: Enhances computational performance to run simulations in seconds to minutes on standard hardware.
• Intervention simulation: Includes built-in tools for simulating commonly-used interventions such as prophylactic vaccines and screening methods.
• Disease progression modeling: Implements a novel methodology for modeling cervical disease progression that is readily adaptable to new forms of screening.
• Flexible parameterization: Supports country-specific vital dynamics and can be adapted to evaluate current and future strategies for cervical cancer elimination.

Scientific Applications:

• Cervical cancer elimination strategy evaluation: Identifies optimal combinations of current and future interventions including vaccines, screening technologies, and treatments to meet WHO targets for cervical cancer elimination.
• HPV genotype dynamics: Models transmission and interaction of multiple co-transmitting HPV genotypes within structured sexual networks.
• Screening method assessment: Evaluates performance of existing and emerging cervical cancer screening approaches through adaptable disease progression modeling.
• In-country policy modeling: Enables local capacity for detailed mechanistic modeling of HPV interventions using country-specific demographic and epidemiological parameters.

Methodology:

HPVsim is implemented in Python using agent-based modeling with structured sexual networks, country-specific vital dynamics, and multiscale modeling functionality for enhanced performance.