HRRD

HRRD curates regulatory interactions between Human Papillomavirus (HPV) — a small double-stranded DNA virus associated with cancers — and host RNA molecules (mRNA, miRNA, lncRNA) to support studies of HPV-driven carcinogenesis and prognostic biomarker discovery.

Key Features:

• Comprehensive Data Compilation: Aggregates curated interaction information from 10,761 scientific papers indexed in PubMed (as of December 1st, 2019).
• Genotype Mapping: Provides a sequence map covering 198 distinct HPV genotypes for genotype-specific analyses.
• Integration of Interaction Data: Integrates regulatory relationships across mRNA, miRNA, and lncRNA to present multi-layered HPV–host RNA interactions.

Scientific Applications:

• Carcinogenesis Research: Supports investigation of molecular mechanisms by which HPV genes interact with host RNA to drive oncogenic processes.
• Prognostic Studies: Facilitates identification of potential prognostic biomarkers and therapeutic targets based on HPV–host RNA interactions.
• Genotype-Specific Analysis: Enables comparative analyses of how different HPV genotypes contribute to disease variability and outcomes.

Methodology:

Data were manually curated and interaction information was extracted from PubMed-indexed scientific literature.