human-gpDB

human-gpDB curates and organizes experimentally supported interactions among human G-protein-coupled receptors (GPCRs), G-proteins, and effectors to support analysis of G-protein signaling pathways.

Key Features:

• Content scope: Contains data on 713 human GPCRs, 36 human G-proteins, and 99 human effectors.
• Interaction dataset: Includes 1,663 GPCR–G-protein interactions and 1,618 G-protein–effector connections, manually curated from the literature.
• Relational database: Implemented as a relational database to store entities and interactions.
• Hierarchical classification: Organizes G-proteins and GPCRs into classes, families, and sub-families and classifies effectors into families, subfamilies, and types based on function.
• IUPHAR-aligned GPCR classification: Adopts IUPHAR guidelines for GPCR classification.
• Data integration and visualization: Integrates external data sources and supports visualization of interaction networks.

Scientific Applications:

• Disease research: Supports investigation of molecular mechanisms underlying human diseases via GPCR signaling analysis.
• Drug discovery: Supports target identification and characterization in pharmaceutical research focused on GPCR signaling.
• Signaling pathway analysis: Enables mapping and analysis of GPCR–G-protein–effector signaling networks for basic and applied biomedical studies.

Methodology:

Data were collected by extensive literature search, manually curated, integrated from external data sources, and organized in a relational database.