HuskinDB

HuskinDB curates and organizes measured skin permeation data for xenobiotics, including drugs in topical formulations, cosmetics, and environmental toxins, to support analysis of small organic compound skin permeation.

Key Features:

• Comprehensive Data Collection: Aggregates skin permeation measurements from the literature for xenobiotics, including topical drugs, cosmetics, and environmental toxins, with associated metadata.
• Experimental Condition Metadata: Records experimental details such as skin source site, specific skin layer used, preparation techniques, storage conditions, temperature, pH, and donor and acceptor solution types.
• Physicochemical Analysis: Provides physicochemical property information and chemical space coverage to inform the applicability domain of permeation data points.
• Experimental Protocol Documentation: Documents experimental protocols and test conditions to contextualize permeation values and support reproducibility of experimental results.

Scientific Applications:

• Topical formulation development: Inform design and optimization of drugs in topical formulations using compiled permeability data.
• Risk assessment: Support safety and exposure assessments for environmental toxins and cosmetic ingredients through aggregated permeation measurements.
• Mechanistic research: Enable fundamental studies of skin absorption mechanisms for small organic compounds by providing structured experimental data.

Methodology:

Aggregates literature measurements and systematically structures experimental conditions and protocol metadata for each permeation measurement.