I-PV

I-PV generates interactive Circos-based circular visualizations of protein sequences by integrating conservation information and single nucleotide variant (SNV) data for comparative and variant analysis.

Key Features:

• Interactive Circos module: Generates interactive circular visualizations using the Circos framework.
• User-supplied data integration: Accepts protein sequences, conservation information, and single nucleotide variant (SNV) data for layered visualization.
• Live-presentable visualizations: Produces interactive, live-presentable outputs that display multiple data layers simultaneously.

Scientific Applications:

• Protein conservation analysis: Visualizes conservation information alongside protein sequences to support conservation analysis.
• Variant impact assessment: Displays SNV data in the context of sequence and conservation to assist assessment of variant impact.
• Comparative genomics: Enables comparison of multiple protein sequences and annotations within a single circular plot for comparative analyses.
• Visualization for hypothesis generation: Presents complex multi-layer protein datasets to aid hypothesis generation and experimental design.

Methodology:

Integrates user-provided protein sequences, conservation information, and SNV data with the Circos framework to produce multi-layered interactive circular plots.