iLINCS

iLINCS integrates and analyzes omics signatures to compare user-submitted and pre-computed datasets for studying disease-, drug-, and mechanism-of-action-associated molecular perturbations.

Key Features:

• Extensive Data Compendium: Hosts over 200,000 pre-computed signatures and more than 12,000 omics datasets.
• Multi-omics and Bioinformatics Tool Integration: Integrates multiple omics data types and connects with external bioinformatics tools and resources.
• Integrative Analytics Workflows: Provides workflows that compare user-submitted omics data with pre-computed signatures to explore cellular perturbations and disease mechanisms.
• Mechanism-of-Action and Drug Repositioning Support: Enables mechanism-of-action analysis and signature-driven drug repositioning through signature similarity and comparison analyses.
• Interactive Visualization of Signatures and Pathways: Includes visualization tools to explore connections between omics signatures and biological pathways.

Scientific Applications:

• Mechanism of Action Analysis: Analyze how drugs or compounds perturb biological pathways at the molecular level using signature comparisons.
• Signature-Driven Drug Repositioning: Identify potential new indications for existing drugs by matching disease and perturbation omics signatures.
• Disease Signature Analysis: Compare disease-associated omics data against the iLINCS repository to investigate disease mechanisms and nominate biomarkers.
• Cellular Perturbation and Pathway Exploration: Study cellular responses and pathway-level effects across perturbations and conditions.

Methodology:

Integrates user-submitted omics data with pre-computed signatures and datasets via analytics workflows that perform signature comparisons and visualization.