IBDkin

IBDkin estimates pairwise kinship coefficients from identity by descent (IBD) segments to quantify genetic relatedness in large genomic datasets.

Key Features:

• IBD-based kinship estimation: Analyzes shared identity by descent (IBD) segments between pairs of individuals to estimate kinship coefficients.
• Scalability: Handles up to hundreds of billions of IBD segments across hundreds of thousands of individuals for large-scale genomic studies.
• Efficiency: Implemented in C and optimized for rapid computation of kinship coefficients on extensive datasets.

Scientific Applications:

• Population and family-based studies: Supports population genetics and family-based association studies that require accurate pairwise kinship estimation.
• Large biobank analysis: Applied to estimate kinship coefficients for 7.95 billion pairs in the UK Biobank among pairs sharing at least one detected IBD segment of ≥ 4 centiMorgans (cM).

Methodology:

Estimates kinship coefficients by analyzing identity by descent (IBD) segments shared between pairs of individuals.