ICE

ICE manages a registry of biological parts and supports legacy and modern assembly standards to organize DNA components, plasmids, microbial host strains, and Arabidopsis seeds for synthetic biology, genetic engineering, and metabolic pathway design.

Key Features:

• Registry scope: Stores and organizes DNA components, plasmids, microbial host strains, and Arabidopsis seeds.
• Assembly standards support: Supports both legacy and modern assembly standards for sequence representation and part composition.
• Web of registries: Implements a distributed "web of registries" concept for integration and sharing of parts information across systems.
• Web APIs: Exposes Web Application Programming Interfaces for automated retrieval and programmatic access to registry data.
• Graphical sequence applications: Provides browser-based graphical applications for sequence annotation, manipulation, and analysis.
• Open-source platform: Distributed as open-source software to allow extension and customization of registry functionality.

Scientific Applications:

• Genetic engineering: Centralizes characterized parts needed for designing and assembling engineered constructs.
• Metabolic pathway design: Organizes parts and plasmids used in constructing and testing synthetic metabolic pathways.
• Bioenergy research: Serves as a parts repository for engineering organisms and pathways relevant to bioenergy projects.
• Agricultural biotechnology: Manages seed and strain information applicable to plant and crop engineering efforts.
• Microbial engineering: Supports storage and retrieval of strains and plasmids used in microbial strain engineering.

Methodology:

Implements a web-of-registries architecture to enable distributed integration and data sharing, exposes Web Application Programming Interfaces, and includes graphical sequence annotation, manipulation, and analysis applications.