IDACombo Shiny App

IDACombo Shiny App predicts drug combination efficacy using monotherapy response data and the Independent Drug Action (IDA) model.

Key Features:

• Monotherapy-based prediction: Generates efficacy predictions for drug combinations using only single-agent response data.
• Integrated cell line screen data: Includes provided data from several high-throughput cell line screens for immediate analysis.
• Custom data support: Accepts user-provided monotherapy data for generating combination predictions.

Scientific Applications:

• Cancer drug combination development: Supports researchers in identifying novel drug combinations for cancer treatment.
• Clinical trial prediction: Provides predictions that have shown strong agreement with measured drug combination efficacy in clinical trials.
• In vitro combination screening: Enables prediction of combination efficacy validated against in vitro measurements.

Methodology:

IDACombo applies the assumptions of independent drug action to monotherapy response data to predict combination efficacy.