idpr

'idpr' (Intrinsically Disordered Proteins in R) is an R package designed for the computational analysis of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs). IDPs and IDRs are characterized by their lack of a single native structure, allowing them to adopt multiple conformations rapidly. These proteins play crucial roles in various biological processes, and the emerging field of "unstructured biology" has been fueled by computational studies identifying the unique characteristics of IDPs and IDRs.
'idpr' provides several R functions that match established characteristics of IDPs to protein sequences of interest. These functions include calculations of residue composition, charge-hydropathy relationships, and intrinsic disorder predictions. Additionally, the package integrates various amino acid substitution matrices and calculators to enhance workflows related to IDPs.

Topic

Small molecules;Protein folds and structural domains;Protein disordered structure;Proteomics;Protein properties

Detail

  • Operation: Protein disorder prediction;Protein secondary structure prediction (coils);Protein structure prediction;Protein hydropathy calculation

  • Software interface: Library

  • Language: R

  • License: GNU Lesser General Public License v3.0

  • Cost: Free

  • Version name: 1.12.0

  • Credit: National Institutes of Health (NIH).

  • Input: -

  • Output: -

  • Contact: William M. McFadden wmm27@pitt.edu

  • Collection: -

  • Maturity: Stable

Publications

  • idpr: A package for profiling and analyzing Intrinsically Disordered Proteins in R.
  • McFadden WM and Yanowitz JL. idpr: A package for profiling and analyzing Intrinsically Disordered Proteins in R. idpr: A package for profiling and analyzing Intrinsically Disordered Proteins in R. 2022; 17:e0266929. doi: 10.1371/journal.pone.0266929
  • https://doi.org/10.1371/JOURNAL.PONE.0266929
  • PMID: 35436286
  • PMC: PMC9015136

Download and documentation


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