iexpressyouRcell
iexpressyouRcell visualizes multi-dimensional gene expression and protein level dynamics as dynamic cellular pictographs and thematic maps to aid interpretation of single-cell RNA sequencing (RNA-seq), bulk RNA-seq, and proteomics data.
Key Features:
- Multi-Dimensional Visualization: Maps variations in transcript and protein levels across multiple dimensions into pictographic representations.
- Dynamic Cellular Pictographs: Generates dynamic cellular pictographs to represent gene expression and protein level changes across measurements such as time points and single-cell trajectories.
- Flexibility Across Data Types: Applies to single-cell RNA sequencing (RNA-seq), bulk RNA-seq, and proteomics datasets.
- Thematic Mapping from Quantitative Data: Converts quantitative expression and protein-level data into thematic maps.
- R-based Implementation: Implements visualization and data transformation using R programming capabilities.
Scientific Applications:
- Temporal Dynamics: Visualization of gene expression and protein-level changes over time series experiments.
- Spatial and Contextual Mapping: Mapping expression variation across spatial contexts or experimental conditions.
- Single-Cell Transcriptomics: Representation of single-cell RNA-seq trajectories and cell-type-specific expression patterns.
- Proteomics Integration: Joint visualization of proteomics and transcriptomics data to interpret protein-level changes alongside gene expression.
Methodology:
Transforms gene expression and proteomics data into thematic maps and dynamic pictographs by leveraging R programming to encapsulate multi-dimensional variations in transcript and protein levels.
Topics
Details
- License:
- MIT
- Cost:
- Free of charge
- Tool Type:
- library
- Operating Systems:
- Mac, Linux, Windows
- Programming Languages:
- R
- Added:
- 1/10/2024
- Last Updated:
- 11/24/2024
Operations
Publications
Paganin M, Tebaldi T, Lauria F, Viero G. Visualizing gene expression changes in time, space, and single cells with expressyouRcell. iScience. 2023;26(6):106853. doi:10.1016/j.isci.2023.106853. PMID:37250782. PMCID:PMC10220493.
PMID: 37250782
PMCID: PMC10220493
Funding: - Fondazione Telethon: GGP19115
- Associazione Italiana per la Ricerca sul Cancro: 24883