iexpressyouRcell

iexpressyouRcell visualizes multi-dimensional gene expression and protein level dynamics as dynamic cellular pictographs and thematic maps to aid interpretation of single-cell RNA sequencing (RNA-seq), bulk RNA-seq, and proteomics data.


Key Features:

  • Multi-Dimensional Visualization: Maps variations in transcript and protein levels across multiple dimensions into pictographic representations.
  • Dynamic Cellular Pictographs: Generates dynamic cellular pictographs to represent gene expression and protein level changes across measurements such as time points and single-cell trajectories.
  • Flexibility Across Data Types: Applies to single-cell RNA sequencing (RNA-seq), bulk RNA-seq, and proteomics datasets.
  • Thematic Mapping from Quantitative Data: Converts quantitative expression and protein-level data into thematic maps.
  • R-based Implementation: Implements visualization and data transformation using R programming capabilities.

Scientific Applications:

  • Temporal Dynamics: Visualization of gene expression and protein-level changes over time series experiments.
  • Spatial and Contextual Mapping: Mapping expression variation across spatial contexts or experimental conditions.
  • Single-Cell Transcriptomics: Representation of single-cell RNA-seq trajectories and cell-type-specific expression patterns.
  • Proteomics Integration: Joint visualization of proteomics and transcriptomics data to interpret protein-level changes alongside gene expression.

Methodology:

Transforms gene expression and proteomics data into thematic maps and dynamic pictographs by leveraging R programming to encapsulate multi-dimensional variations in transcript and protein levels.

Topics

Details

License:
MIT
Cost:
Free of charge
Tool Type:
library
Operating Systems:
Mac, Linux, Windows
Programming Languages:
R
Added:
1/10/2024
Last Updated:
11/24/2024

Operations

Publications

Paganin M, Tebaldi T, Lauria F, Viero G. Visualizing gene expression changes in time, space, and single cells with expressyouRcell. iScience. 2023;26(6):106853. doi:10.1016/j.isci.2023.106853. PMID:37250782. PMCID:PMC10220493.

PMID: 37250782
Funding: - Fondazione Telethon: GGP19115 - Associazione Italiana per la Ricerca sul Cancro: 24883