IGV

IGV visualizes integrated genomic and array-based datasets to enable exploration and interpretation of sequencing and profiling results.

Key Features:

• High-Performance Visualization: Provides optimized, multi-resolution visualization for large and heterogeneous genomic datasets to enable smooth navigation at all genome resolution levels.
• Data Integration and Formats: Supports array-based profiling and next-generation sequencing data, including short-read alignments in SAM and BAM formats.
• Multi-Modal Data Integration: Integrates sequencing and array data alongside clinical and phenotypic information for combined visualization and comparison.
• Remote and Local Data Access: Supports loading and streaming of datasets from local files and remote sources, including HTTP-accessible files.
• JavaScript Implementation (igv.js): Provides a JavaScript implementation, igv.js, that implements the core viewer functionality for embedding into computational environments.

Scientific Applications:

• Genomic Variation Analysis: Visualization of genomic variants and structural changes derived from sequencing data to support variant interpretation.
• Gene Expression and Profiling Comparison: Comparative visualization of gene expression patterns and array-based profiling alongside sequencing-derived signals.
• Translational and Clinical Genomics: Integration of sequencing and phenotypic/clinical data to support analyses in clinical and translational research contexts.

Methodology:

Efficient handling and multi-resolution visualization of large, heterogeneous sequencing and array-based datasets, including streaming of short-read alignments in SAM/BAM formats.