IMGT database of human MHC

IMGT database of human MHC provides a curated repository of Human Leukocyte Antigen (HLA) sequences to support immunogenetics research and clinical applications.

Key Features:

• Curated repository: Meticulously curated collection of HLA gene and allele sequences for research and clinical use.
• Regular updates: Periodic incorporation of new sequences and confirmatory data to maintain current HLA allele information.
• Standardized nomenclature: Sequence naming and allele designations follow the WHO Nomenclature Committee for Factors of the HLA System.
• Collaborative curation: Data curation and maintenance are performed in collaboration with the HLA Informatics Group and the European Bioinformatics Institute (EBI).

Scientific Applications:

• Immunogenetics research: Provides detailed genetic information on highly polymorphic HLA genes to support studies of immune system function and genetic variation.
• Clinical studies: Enables analyses of HLA variation related to disease susceptibility, organ transplantation compatibility, and personalized medicine.
• Quality control and standardization: Supplies standardized allele names and reference sequences to support reproducibility and comparability across studies.

Methodology:

Rigorous curation and validation of submitted HLA sequences with naming and verification according to WHO Nomenclature Committee for Factors of the HLA System guidelines.