IMGT HLA Sequence Alignment

IMGT HLA Sequence Alignment performs sequence alignments to compare and analyze HLA and Major Histocompatibility Complex (MHC) gene polymorphisms using IMGT/HLA reference data.

Key Features:

• Interactive sequence alignment: Enables detailed examination of polymorphisms through interactive alignment of input sequences.
• IMGT/HLA Database integration: Aligns sequences against curated reference sequences from the IMGT/HLA Database within the IPD project.
• MHC/HLA locus support: Focuses on locus-specific variation in HLA and other MHC genes across species as curated by IPD.
• Next Generation Sequencing compatibility: Accepts and accommodates sequences derived from Next Generation Sequencing technologies.

Scientific Applications:

• HLA polymorphism analysis: Comparative analysis of HLA alleles and MHC gene variants for immunogenetic studies.
• Locus-specific database curation: Support for curation and nomenclature maintenance of locus-specific databases within the IPD framework.
• Research and clinical HLA typing: Application to research investigations and clinical contexts requiring precise HLA sequence comparison.
• Sequence publication and confirmation: Facilitates generation and reporting of new and confirmatory HLA sequences for the immunogenetics community.

Methodology:

Performs sequence alignments against IMGT/HLA Database reference sequences and accepts sequences generated by Next Generation Sequencing.