ImmReg

ImmReg maps and analyzes regulons of transcription factors, microRNAs, RNA binding proteins, and long noncoding RNAs within immune-related pathways across multiple cancer types to elucidate gene regulation perturbations relevant to cancer immunity.

Key Features:

• Comprehensive Landscape Mapping: Charts regulons involving transcription factors, microRNAs, RNA binding proteins, and long noncoding RNAs across 17 immune-related pathways in 33 cancer types, highlighting regulons with higher expression in immune cells and perturbations in cancerous tissues.
• Correlation with Immune Cell Infiltration: Identifies regulons significantly correlated with immune cell infiltration to associate regulon activity with tumor microenvironment composition.
• Clinically Relevant Regulons Identification: Highlights a panel of clinically relevant immunology regulons across cancers, including ETV7, miR-146a-5p, ZFP36, and HCP5, as candidates for RNA-based cancer immunotherapies.
• Molecular Subtype Characterization: Aids identification of molecular subtypes exemplified by two glioma phenotypes (cold and hot) that differ in immune cell infiltration, immune checkpoint molecule expression, and patient prognosis.

Scientific Applications:

• Cancer immunotherapy target discovery: Enables identification of regulons and RNA targets to support development of RNA-based immunotherapeutic strategies.
• Prognostic stratification and personalized therapy: Facilitates distinction of molecular subtypes based on immune characteristics to refine prognostic assessment and inform personalized treatment decisions.

Methodology:

Systematic identification and analysis of regulons (transcription factors, microRNAs, RNA binding proteins, and long noncoding RNAs) across 17 immune-related pathways in 33 cancers, with correlation analyses between regulon activity, immune cell infiltration, and clinical characteristics, and molecular subtype characterization exemplified for glioma.