ImmunoDB

ImmunoDB provides curated gene family assignments, functional annotations, and phylogenetic data for insect immune-system genomics to support comparative phylogenomic analysis across Aedes aegypti (Aa), Anopheles gambiae (Ag), and Drosophila melanogaster (Dm).

Key Features:

• Gene family assignments and annotations: Provides gene family assignments and functional annotations for immune-related genes in Aedes aegypti (Aa), Anopheles gambiae (Ag), and Drosophila melanogaster (Dm).
• Phylogenetic data and comparative phylogenomics: Enables comparative phylogenomic analyses using genome sequences from multiple insect species to compare immune gene families and evolutionary relationships.
• Immune signaling pathways analysis: Analyzes immune signaling pathways and response modules across species to identify conserved and rapidly evolving components.
• Functional gene category insights: Characterizes how specific functional gene categories contribute to various aspects of immune reactions.
• Evolutionary dynamics assessment: Provides data and analyses to assess conserved elements and rapidly evolving features within insect immune repertoires.

Scientific Applications:

• Vector-borne disease research: Supports investigation of the genetic basis of insect immunity relevant to control of mosquito-borne diseases such as yellow fever and Dengue.
• Evolutionary immunology: Enables study of how innate immune systems have evolved through adaptation, balancing pathogen accommodation and rejection.
• Comparative and functional genomics: Facilitates comparative genomic and functional analyses in immunology, genomics, and vector biology using genome sequences from Aa, Ag, and Dm.

Methodology:

Performs comparative phylogenomic analysis of genome sequences from Aedes aegypti, Anopheles gambiae, and Drosophila melanogaster to assign immune-related gene families, provide annotations and phylogenetic data, and identify evolutionary trends within immune genes.