ImmunoGlobe

ImmunoGlobe provides a manually curated intercellular immune interaction network that maps the human immune interactome to support systems-immunology analyses.

Key Features:

• Manually Curated Network: The network was constructed from authoritative immunological sources, including Janeway's Immunobiology textbook.
• Directed Graph: The resource represents a directed graph comprising 253 distinct immune system components interconnected by 1112 unique interactions.
• Interaction Annotation: Each of the 1112 interactions is annotated with detailed functional and characteristic information.
• Novel Insights: Network analysis enables identification of novel multi-step immune pathways, assessment of species-specific differences in immune processes, and prediction of cellular responses to stimuli.
• Standardized Interaction Map: Provides a standardized map to translate high-resolution profiling data into mechanistic insights.

Scientific Applications:

• Understanding Immune Mechanisms: Translates high-resolution profiling data into actionable mechanistic insights about immune interactions.
• Predictive Modeling: Supports modeling of complex immune interactions to derive mechanistic hypotheses for modulating immune responses in health and disease.
• Cross-Disciplinary Utility: Offers a network-analysis resource specifically tailored to immunology complementing existing approaches in proteomics and genomics.

Methodology:

Data were extracted from established immunological literature and manually curated to construct a directed network mapping 253 immune components and 1112 annotated interactions.