iMutSig

iMutSig compares mutational signatures from COSMIC and pmsignature by converting pmsignature outputs into COSMIC-compatible 96-category probabilistic vectors and quantifying similarity with cosine similarity to support analysis of nucleotide mutation patterns in cancer.

Key Features:

• Data Integration: Integrates signature data from the Catalogue Of Somatic Mutations In Cancer (COSMIC) and the pmsignature method for direct comparison.
• pmsignature Expansion: Expands pmsignature output into probabilistic vectors representing the 96 possible mutation types aligned to the COSMIC model specification.
• Cosine Similarity Analysis: Quantifies similarity between mutational signature vectors using cosine similarity.
• Custom Signature Input: Accepts user-defined mutational signatures for comparison against COSMIC and pmsignature signatures.

Scientific Applications:

• Cross-framework comparison: Enables assessment of methodological discrepancies between COSMIC and pmsignature-derived signatures.
• Interpretation of mutational processes: Supports analysis of nucleotide mutation patterns to infer underlying biological processes in cancer.
• Clinical and translational research: Aids investigations into mutation origins and implications for potential therapeutic targets and personalized medicine.

Methodology:

Integrates COSMIC and pmsignature data, expands pmsignature outputs into 96-type probabilistic vectors aligned with the COSMIC model specification, and computes cosine similarity between signature vectors.