InCroMAP

InCroMAP integrates heterogeneous microarray datasets from mRNA, miRNA, DNA methylation, and protein modification platforms to enable integrated analysis and pathway-centered visualization of molecular regulation across identical biological samples.

Key Features:

• Multi-Platform Support: Supports combined analysis of mRNA, miRNA, DNA methylation, and protein modification microarray datasets from identical biological samples.
• microRNA Target Annotation: Annotates microRNA targets to link miRNA signals with putative mRNA targets.
• Integrated Gene Set Enrichment Analysis: Performs integrated gene set enrichment analysis across multiple platforms to identify coordinated functional changes.
• Joint Pathway Visualization: Provides joint visualization techniques that contextualize multi-platform data within metabolic and signaling pathways.
• DNA Methylation Visualization: Visualizes detailed DNA methylation patterns alongside other molecular data.
• Pathway-Based Analysis: Enables pathway-centric interpretation of molecular changes across datasets to elucidate functional implications.

Scientific Applications:

• Integrated multi-omics studies: Enables combined analysis of gene expression, epigenetic modification, and protein modification data to study complex regulatory relationships.
• Disease mechanism analysis: Supports identification of coordinated molecular alterations relevant to disease processes.
• Drug discovery: Facilitates analysis of multi-platform molecular responses relevant to compound effects and target validation.
• Personalized medicine: Assists multi-platform molecular profiling to inform individualized models of disease and treatment response.

Methodology:

Annotation of microRNA targets, integrated gene set enrichment analysis, and joint pathway-based visualization of mRNA, miRNA, DNA methylation, and protein modification data.