Nucleotide Sequence Database Collaboration

Nucleotide Sequence Database Collaboration coordinates collection, curation, and dissemination of DNA and RNA nucleotide sequence data among the DNA Data Bank of Japan (DDBJ), the European Molecular Biology Laboratory's European Bioinformatics Institute (EMBL-EBI), and the National Center for Biotechnology Information (NCBI) to provide a unified public repository of raw reads, alignments, assemblies, functional annotations, and sample metadata.

Key Features:

• Collaborative data exchange: Synchronizes nucleotide sequence records among DDBJ, EMBL-EBI, and NCBI to maintain a unified international dataset.
• Data types stored: Houses DNA and RNA sequence data including raw reads, alignments, and assemblies.
• Functional annotations: Includes functional annotations linked to sequence records.
• Sample and experimental metadata: Stores contextual information related to samples and experimental setups alongside sequences.
• Data-sharing policy: Operates under a data-sharing policy endorsed by the International Advisory Committee that emphasizes voluntary cooperation and free global access.
• Curation: Collects and curates submitted sequence data to produce standardized records.

Scientific Applications:

• Genomics: Provides sequence and assembly resources that support genome-scale analyses and comparative genomics.
• Molecular biology: Supplies nucleotide sequences and annotations used in molecular biology research and experimental design.
• Open-data research and reproducibility: Enables open access to sequence data to support reproducible analyses and cross-study comparisons.

Methodology:

Collects, curates, and disseminates nucleotide sequence records and associated annotations and metadata across the participating databases.