IntAct

IntAct provides a curated database of molecular interactions for storage and analysis of protein–protein interactions.

Key Features:

• Curated interaction repository: Manually curated protein–protein interaction records aggregated from literature curation and direct data depositions.
• Curation tool: Supports annotation at IMEx- and MIMIx-levels to enable standardized documentation of molecular interactions.
• Quality control: Applies rigorous quality control on curated interaction entries.
• Collaborative curation: Accepts contributions from multiple curation teams.
• MINT integration: Integrates manually curated data from MINT into the IntAct database at EMBL-EBI.
• IMEx consortium participation: Participates in the IMEx (International Molecular Exchange) consortium to support data standardization and integration across databases.
• Open-source: Distributed as an open-source molecular interaction database.

Scientific Applications:

• Curation and aggregation: Generation of comprehensive, curated protein interaction datasets for bioinformatics research.
• Data standardization: Standardization and integration of molecular interaction data across multiple databases via IMEx.
• Network analysis: Support for analysis of interaction networks to study complex biological processes.

Methodology:

Data are acquired by literature curation and direct data depositions, annotated at IMEx- and MIMIx-levels, and manually curated data from MINT have been integrated into IntAct at EMBL-EBI.