INTEDE

INTEDE provides a curated database of interactions involving drug-metabolizing enzymes (DMEs) to support analysis of microbiome-DME (MICBIO), xenobiotic-DME (XEOTIC), and host protein-DME (HOSPPI) relationships underlying drug metabolism and precision medicine.

Key Features:

• Comprehensive DME Confirmation: 1047 unique DMEs were confirmed, comprising 448 host and 599 microbial enzymes, based on their metabolizing drugs.
• Extensive Interaction Data Collection: The database includes 3,359 MICBIO interactions between 225 microbial species and 185 DMEs; 47,778 XEOTIC interactions involving 4,150 xenobiotics and 501 DMEs; and 7,849 HOSPPI interactions among 565 human proteins and 566 DMEs.
• Facilitation of Crosstalk Analysis: Integration of MICBIO, XEOTIC, and HOSPPI data enables analysis of crosstalk among microbial, xenobiotic, and host-protein influences on drug metabolism.
• Implications for Precision Medicine: Collective consideration of these interaction types supports identification of signatures relevant to disease etiology and optimization of clinical treatment strategies.

Scientific Applications:

• Pharmacokinetics and pharmacodynamics analysis: Supports investigation of how DMEs modulate drug absorption, distribution, metabolism, and excretion across microbial, xenobiotic, and host-protein contexts.
• Prediction of drug responses and adverse effects: Provides interaction data to improve prediction of individual and population-level drug responses and toxicity.
• Precision medicine strategy development: Informs personalization of treatment plans by accounting for microbial, xenobiotic, and host-protein interactions with DMEs.
• Mechanistic studies of microbial and xenobiotic influences: Enables analysis of species-specific microbial enzymes and xenobiotic compounds that alter DME activity.

Methodology:

DME confirmation was performed through their metabolizing drugs and interaction data were compiled across the MICBIO, XEOTIC, and HOSPPI categories.